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Restoring 
Neuronal Homeostasis

through the activation of SIGMAR1

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Our proprietary SIGMACEPTOR Discovery Platform produces small molecule therapeutic candidates, like ANAVEX®2-73, with novel modes of action. 

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SIGMAR1 prevents toxic RNA from translating into proteins

(post-transcription)

ANAVEX®2-73 bound to SIGMAR1

SIGMAR1 protects healthy gene expression through Chromatin Remodeling

(pre-transcription)

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SIGMAR1

ANAVEX®2-73

When activated by SIGMAR1 agonists, like ANAVEX®2-73, SIGMAR1 reduces cellular stress before and after RNA gene transcription. Studies confirm the predictive biomarker of response established through SIGMAR1 mRNA expression.

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Because of its role in maintaining neuronal homeostasis, sigma receptors show significant promise as viable targets for therapeutic molecules in an effort to address a variety of CNS conditions.