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Restoring
Neuronal Homeostasis
through the activation of SIGMAR1

Our proprietary SIGMACEPTOR™ Discovery Platform produces small molecule therapeutic candidates, like ANAVEX®2-73, with novel modes of action.

SIGMAR1 prevents toxic RNA from translating into proteins
(post-transcription)
ANAVEX®2-73 bound to SIGMAR1
SIGMAR1 protects healthy gene expression through Chromatin Remodeling
(pre-transcription)


SIGMAR1
ANAVEX®2-73
When activated by SIGMAR1 agonists, like ANAVEX®2-73, SIGMAR1 reduces cellular stress before and after RNA gene transcription. Studies confirm the predictive biomarker of response established through SIGMAR1 mRNA expression.
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