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Alzheimer’s Disease Alzheimer’s disease is a progressive, irreversible neurological disease and the most According to the World Alzheimer Report 2019, the current annual cost of dementia is estimated at $1 (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated Research & Business Development Toll-free: 1-844-689-3939 Email: info@anavex.com Investors & Media: and Biology Volume 964 (2017) Sigma Receptors: Their Role in Disease and as Therapeutic Targets [2] https

of response and applying precision medicine for treatment of neurological disorders with high unmet medical billion, with the cost expected to increase to more than $1 trillion as the population ages. Most of the direct costs of care for Alzheimer’s disease are attributed to skilled nursing care, home Indirect costs of care, including quality of life and informal caregiving, are likely underestimated Barwicki Investor Relations Tel: 516-662-9461 Email: andrew@barwicki.com [1] https://fragilex.org/understanding-fragile-x

improvements in the Cognitive Drug Research (CDR) computerized assessment system analysis Company to host ANAVEX®2-73-PDD-001 study results will be submitted for presentation at a medical conference and for publication in a peer-reviewed medical journal. There has not been a mechanistically novel medication approved for PDD in over 20 years.” The webcast can be accessed at https://wsw.com/webcast/cc/avxl15/1496358 and on the Company’s website

In 2020, Alzheimer's and other dementias cost the nation $305 billion. By 2050, these costs could rise as high as $1.1 trillion.[1] There are currently over 50 million people Barwicki Investor Relations Tel: 516-662-9461 Email: andrew@barwicki.com [1] https://www.nia.nih.gov/ health/alzheimers; https://www.alz.org/alzheimers-dementia/facts-figures. [2] Alzheimer's Disease International World Alzheimer Report 2019. https://www.alz.co.uk/research/WorldAlzheimerReport2019.pdf. [3] AARP. 2020

2030, according to the European Brain Council. [2] The World Health Organization (WHO) estimated the cost care, medicines, diagnostics, informal caregiver time, community services and long-term care facility costs (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of novel therapeutics projected in any of such statements due to various factors, including the risks set forth in the Company’s most Alzheimers Dement. 2024;20(5):3352-3363. doi:10.1002/alz.13770 [2]  https://www.braincouncil.eu/projects

Kaufmann, M.D. to Chief Scientific Officer and Appoints Edward R Hammond, M.D., M.P.H, Ph.D., as Chief Medical promoted to Chief Scientific Officer and Edward R Hammond, M.D., M.P.H., PhD, has been appointed Chief Medical Kaufmann was a Professor of Neurology at Harvard Medical School and a Professor of Pathology, Neurology Hammond’s focus is on an integrative, innovative, and efficient drug development continuum for which published over 60 full scientific manuscripts and book chapters and served as a reviewer for several medical

Alzheimer’s Disease (CTAD) Congress 2022 in San Francisco, CA and publish the findings in a peer-reviewed medical The estimated total healthcare costs for the treatment of Alzheimer's disease in 2020 were estimated at $305 billion, with the cost expected to increase to more than $1 trillion as the population ages. Most of the direct costs of care for Alzheimer's disease are attributed to skilled nursing care, home Indirect costs of care, including quality of life and informal caregiving, are likely underestimated,

Alzheimer’s Disease Alzheimer’s disease is a progressive, irreversible neurological disease and the most According to the World Alzheimer Report 2019, the current annual cost of dementia is estimated at $1 (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated Research & Business Development Toll-free: 1-844-689-3939 Email: info@anavex.com Investors & Media: Email: ir@anavex.com [1] https://www.alz.co.uk/research/WorldAlzheimerReport2019.pdf

“There is an unmet medical need around brain illnesses such as Traumatic Brain Injury (TBI) and Post are no more restrictive than the predominant requirements or limitations applied to substantially all medical (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated projected in any of such statements due to various factors, including the risks set forth in the Company’s most Dobson Media Group (203) 258-0159 dennisdobsonjr@dobsonmediagroup.com

Anavex Chief Medical Officer, Walter E. disease Phase 2a extension study[1] has been analyzed, and the results will be presented at a forthcoming medical (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated projected in any of such statements due to various factors, including the risks set forth in the Company’s most Research & Business Development Toll-free: 1-844-689-3939 Email: info@anavex.com Investors & Media:

of response and applying precision medicine for treatment of neurological disorders with high unmet medical Anavex announced a peer-reviewed publication in American Journal of Medical Genetics identifying a blood billion, with the cost expected to increase to more than $1 trillion as the population ages. Most of the direct costs of care for Alzheimer's disease are attributed to skilled nursing care, home Indirect costs of care, including quality of life and informal caregiving, are likely underestimated

The meeting, which will be held in a virtual format only, will be webcast, and can be accessed at: http To be admitted to the Annual Meeting at http://viewproxy.com/Anavex/2020/vm /, you must enter the control (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated projected in any of such statements due to various factors, including the risks set forth in the Company’s most Research & Business Development Toll-free: 1-844-689-3939 Email: info@anavex.com Investors & Media