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  • ABOUT US
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Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands.

PIPELINEBy alessandroOctober 11, 2001

Pharmacol 134, 691-699, (2001). Bermack, J. E., & Debonnel, G. View abstract in PubMed

The antidepressant-like effect induced by sigma-1 receptor agonists and neuroactive steroids in mice submitted to the forced swimming test.

PIPELINEBy alessandroSeptember 11, 2001

J Pharmacol Exp Ther 298, 1269-1279, (2001). Urani, A., Roman, F. J., Phan, V., Su, T. P., & Maurice, T. View abstract in PubMed

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Alzheimer's DiseaseBy alessandroAugust 10, 2001

Journal of Neuropathology and Experimental Neurology Vol. 60, No. 8, August, 2001 Akihiko Nunomura, MD, PH.D., George Perry, PH.D., Gjumrakch Aliev, MD, PH.D., Keisuke Hirai, PH.D., Atsushi Takeda, MD, PH.D., Elizabeth K. Balraj, MD, Paul K. Jones, PH.D., Hossein Ghanbari, PH.D., Takafumi Wataya, MD, Shun Shimohama, MD, PH.D., Shigeru Chiba, MD, PH.D., Craig S. Atwood,…

Molecular cloning and pharmacological characterization of the rat σ1 receptor.

PIPELINEBy alessandroAugust 1, 2001

Biochem Pharmacol 62, 349-355, (2001). Mei, J., & Pasternak, G. W. View abstract in PubMed

Neuroprotective effect of sigma-1 receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production.

PIPELINEBy alessandroJuly 11, 2001

Stroke 32, 1613-1620, (2001). Goyagi, T., Goto, S., Bhardwaj, A., Dawson, V. L., Hurn, P. D., & Kirsch, J. R. View abstract in PubMed

Regulating ankyrin dynamics: Roles of sigma-1 receptors.

PIPELINEBy alessandroJanuary 16, 2001

Proc Natl Acad Sci USA 98, 491-496, (2001). Hayashi, T., & Su, T. P View abstract in PubMed

How cells handle cholesterol.

PIPELINEBy alessandroDecember 1, 2000

Science 290, 1721-1726, (2000). Simons, K., & Ikonen, E View abstract in PubMed

Animal models of Alzheimer’s disease and evaluation of anti-dementia drugs.

Alzheimer's DiseaseBy alessandroNovember 10, 2000

Pharmacol Ther 88, 93-113, (2000). Yamada, K., & Nabeshima, T. View abstract in PubMed

Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference.

PIPELINEBy alessandroSeptember 11, 2000

Neuroreport 11, 2885-2888, (2000). Romieu, P., Martin-Fardon, R., & Maurice, T View abstract in PubMed

Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice.

PIPELINEBy alessandroSeptember 11, 2000

Neuropharmacology 39, 2391-2398, (2000). Mamiya, T., Noda, Y., Noda, A., Hiramatsu, M., Karasawa, K., Kameyama, T., et al. View abstract in PubMed

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