Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumour and self-reliant cells and inhibit tumor growth in vitro and in vivo.

Cancer Res 64, 4875-4886, (2004). Spruce, B. A., Campbell, L. A.,McTavish, N., Cooper, M. A., Appleyard, M. V., O’Neill,M., et al. View abstract in PubMed

Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids.

J Endocrinol 182, 11-21, (2004). Robichaud, M., & Debonnel, G. View abstract in PubMed

Sigma receptors: Biology and therapeutic potential.

Psychopharmacology (Berl) 174, 301-319, (2004). Guitart, X., Codony, X., & Monroy, X. View abstract in PubMed

The sigma receptor ligand (+)pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate.

Brain Res Mol Brain Res 123, 66-75, (2004) Martin, P.M., Ola, M. S., Agarwal, N., Ganapathy, V.,&Smith, S. B. View abstract in PubMed

Functional polymorphisms in the σ1 receptor gene associated with alcoholism.

Biol Psychiatry 55, 85-90, (2004). Miyatake, R., Furukawa, A., Matsushita, S., Higuchi, S., & Suwaki, H. View abstract in PubMed

Sigma-1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats.

Pol J Pharmacol 55, 1149-1152, (2003). Skuza, G., & Rogoz, Z. View abstract in PubMed

Protein kinase Cdependent potentiation of intracellular calcium influx by σ1 receptor agonists in rat hippocampal neurons.

J Pharmacol Exp Ther 307, 705-712, (2003). Monnet, F. P., Morin-Surun, M. P., Leger, J., & Combettes, L. View abstract in PubMed

No association between the sigma receptor type 1 gene and schizophrenia: Results of analysis and meta-analysis of case-control studies.

BMC Psychiatry 3, 13, (2003). Uchida, N., Ujike, H., Nakata, K., Takaki, M., Nomura, A., Katsu, T., et al. View abstract in PubMed

Sigma-1 receptor (s1 binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: Roles in endoplasmic reticulum lipid compartmentalization and export.

J Pharmacol Exp Ther 306, 718-725, (2003b). Hayashi, T., & Su, T. P. View abstract in PubMed

Intracellular dynamics of sigma-1 receptors in NG-108- 15 cells.

J Pharmacol Exp Ther 306, 726-733, (2003a). Hayashi, T., & Su, T. P. View abstract in PubMed