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  • ABOUT US
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Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.

PIPELINEBy alessandroDecember 11, 2006

J Pharmacol Exp Ther 319, 1355-1365, (2006). Katnik, C., Guerrero, W. R., Pennypacker, K. R., Herrera, Y., & Cuevas, J. View abstract in PubMed

The expression and functional characterization of sigma-1 receptors in breast cancer cell lines.

PIPELINEBy alessandroOctober 28, 2006

Cancer Lett 242, 245-257, (2006). Aydar, E., Omganer, P., Perrett, R., Djamgoz, M. B., & Palmer, C. P. View abstract in PubMed

Intrathecal treatment with sigma-1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice.

PIPELINEBy alessandroJune 11, 2006

Br J Pharmacol 148, 490-498, (2006). Kim, H. W., Kwon, Y. B., Roh, D. H., Yoon, S. Y., Han, H. J., Beitz, A. J., et al. View abstract in PubMed

Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1.

PIPELINEBy alessandroJune 11, 2006

Int Immunopharmacol 6, 1029-1033, (2006). Gekker, G., Hu, S., Sheng, W. S., Rock, R. B., Lokensgard, J. R., & Peterson, P. K. View abstract in PubMed

Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats.

PIPELINEBy alessandroMay 11, 2006

Curr Neurovasc Res 3, 89-98, (2006). Ajmo, C. T., Vernon, D. O., Collier, L., Pennypacker, K. R., & Cuevas, J. View abstract in PubMed

A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma-1 receptors.

PIPELINEBy alessandroApril 24, 2006

Eur J Pharmacol 536, 200-203, (2006). Bucolo, C., Marrazzo, A., Ronsisvalle, S., Ronsisvalle, G., Cuzzocrea, S., Mazzon, E., et al. View abstract in PubMed

Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma-1 receptor: Optical imaging study in rat hippocampal slices.

PIPELINEBy alessandroMarch 11, 2006

Neuropharmacology 50, 380-392, (2006). Chen, L., Dai, X. N., & Sokabe, M. View abstract in PubMed

A variant of the sigma receptor type 1 gene is a protective factor for Alzheimer’s disease.

Alzheimer's DiseaseBy alessandroDecember 10, 2005

Am J Geriatr Psychiatry 13, 1062-1066, (2005). Uchida, N., Ujike, H., Tanaka, Y., Sakai, A., Yamamoto, M., Fujisawa, Y., et al. View abstract in PubMed

Inhibition of tumor cell proliferation by sigma ligands is associated with K+channel inhibition and p27kip accumulation.

PIPELINEBy alessandroDecember 11, 2004

J Pharmacol Exp Ther 311, 1105-1114, (2004). Renaudo, A., Watry, V., Chassot, A. A., Ponzio, G., Ehrenfeld, J., & Soriani, O. View abstract in PubMed

Clinical trials with sigma ligands.

PIPELINEBy alessandroNovember 11, 2004

Pharmacopsychiatry 37, S214-S220, (2004). Volz, H. P., & Stoll, K. D. View abstract in PubMed

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