Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumour and self-reliant cells and inhibit tumor growth in vitro and in vivo.

Cancer Res 64, 4875-4886, (2004). Spruce, B. A., Campbell, L. A.,McTavish, N., Cooper, M. A., Appleyard, M. V., O’Neill,M., et al. View abstract in PubMed