“Sigma-1 receptors regulate Bcl-2 expression by ROS-dependent transcriptional regulation of NF-κB” The Journal of Pharmacology and Experimental Therapeutics, October 23, 2009, doi: 10.1124/jpet.109.160960
Johann Meunier, Teruo Hayashi
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“Glioblastoma: Looking at the Currently Marketed Sigma-1 Agonists and Antagonists” Neoplasia. 2007 August; 9(8): 689.
Richard E Kast
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“Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival” Cell (2007), doi:10.1016/j.cell.2007.08.036
Teruo Hayashi and Tsung-Ping Su
View Paper

“Sigma Receptor Agonists Provide Neuroprotection In Vitro by Preserving bcl-2” Neurosurgical Anesthesia, Vol. 104, No. 5, May 2007
Sufang Yang, MD, Anish Bhardwaj, MD, Jian Cheng, PhD, Nabil J. Alkayed, MD, PhD, Patricia D. Hurn, PhD, and Jeffrey R. Kirsch, MD
View Paper

“Oxidative Damage Is the Earliest Event in Alzheimer Disease” Journal of Neuropathology and Experimental Neurology Vol. 60, No. 8, August, 2001
Akihiko Nunomura, MD, PH.D., George Perry, PH.D., Gjumrakch Aliev, MD, PH.D., Keisuke Hirai, PH.D., Atsushi Takeda, MD, PH.D., Elizabeth K. Balraj, MD, Paul K. Jones, PH.D., Hossein Ghanbari, PH.D., Takafumi Wataya, MD, Shun Shimohama, MD, PH.D., Shigeru Chiba, MD, PH.D., Craig S. Atwood, PH.D., Robert B. Petersen, PH.D., AND Mark A. Smith, PH.D.
View Paper

“Apoptosis regulation by Bcl-xL modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating” PNAS, July 24, 2007, vol. 104, no. 30, 12565–12570
Chi Li, Xiaoli Wang, Horia Vais, Craig B. Thompson, J. Kevin Foskett, and Carl White
View Paper

“Predicting the failure of amyloid-beta vaccine” THE LANCET, Vol 359, May 25, 2002
Mark A Smith, Craig S Atwood, James A Joseph, George Perry
View Paper

“Amyloid-beta junkies” THE LANCET, Vol 355, February 26, 2000
George Perry, Akihiko Nunomura, Arun K Raina, Mark A Smith
View Paper

“Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats.” Curr Neurovasc Res 3, 89-98, (2006).
Ajmo, C. T., Vernon, D. O., Collier, L., Pennypacker, K. R., & Cuevas, J.
View abstract in PubMed

“Spreading depression: Imaging and blockade in the rat neocortical brain slice. ” Anderson, J Neurophysiol 88, 2713-2725, (2002).
T. R., & Andrew, R. D.
View abstract in PubMed

“The expression and functional characterization of sigma-1 receptors in breast cancer cell lines. ” Cancer Lett 242, 245-257, (2006).
Aydar, E., Omganer, P., Perrett, R., Djamgoz, M. B., & Palmer, C. P.
View abstract in PubMed

“The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. ” Neuron 34, 399-410, (2002).
Aydar, E., Palmer, C. P., Klyachko, V. A., & Jackson, M. B.
View abstract in PubMed

“Modification of the N-methyl-Daspartate response by antidepressant sigma receptor ligands. ” Eur J Pharmacol 240, 319-323, (1993).
Bergeron, R., Debonnel, G., & De Montigny, C.
View abstract in PubMed

“Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands. ” Br J Pharmacol 134, 691-699, (2001).
Bermack, J. E., & Debonnel, G.
View abstract in PubMed

“Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus. ” Synapse 55, 37-44, (2005a).
Bermack, J. E., & Debonnel, G.
View abstract in PubMed

“The role of sigma receptors in depression. ” J Pharmacol Sci 97, 317-336, (2005b).
Bermack, J. E., & Debonnel, G.
View abstract in PubMed

“Effects of OPC-14523, a combined sigma and 5-HT1a ligand, on pre- and post-synaptic 5-HT1a receptors. ” J Psychopharmacol 21, 85-92, (2007).
Bermack, J. E., & Debonnel, G.
View abstract in PubMed

“Effects of sigma ligands on NMDA receptor function in the bulbectomy model of depression: A behavioural study in the rat. ” Int J Neuropsychopharmacol 5, 53-62, (2002).
Bermack, J., Lavoie, N., Dryver, E., & Debonnel, G.
View abstract in PubMed

“Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5- methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: Modulation of neuronal activity in the dorsal raphe nucleus. ” J Pharmacol Exp Ther 310, 578-583, (2004).
Bermack, J. E., Haddjeri, N., & Debonnel, G.
View abstract in PubMed

“Interactions between 3,4- methylenedioxymethamphetamine and sigma-1 receptors. ” Eur J Pharmacol 553, 141-145, (2006).
Brammer, M. K., Gilmore, D. L., & Matsumoto, R. R.
View abstract in PubMed

“The sigma receptor ligand, reduced haloepridol, induces apoptosis and increases intracellular-free calcium levels [Ca2+]i in colon and mammary adnocarcinoma cell. ” Biochem Biophys Res Commun 219, 219-226, (1996).
Brent, P. J., Pang, G., Little, G., Dosen, P. J., & Van Helden, D. F.
View abstract in PubMed

“Neuroactive steroids protect retinal tissue through sigma- 1 receptors. ” Basic Clin Pharmacol Toxicol 100, 214-216, (2007).
Bucolo, C., & Drago, F.
View abstract in PubMed

“A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma-1 receptors. ” Eur J Pharmacol 536, 200-203, (2006).
Bucolo, C., Marrazzo, A., Ronsisvalle, S., Ronsisvalle, G., Cuzzocrea, S., Mazzon, E., et al.
View abstract in PubMed

“Protective effects of the sigma agonist PRE-084 in the rat retina. ” Br J Ophthalmol 91, 1382-1384, (2007).
Cantarella, G., Bucolo, C., Di Benedetto, G., Pezzino, S., Lempereur, L., Calvagna, R., et al.
View abstract in PubMed

“Formalininduced pain is reduced in sigma-1 receptor knockoutmice. ” Eur J Pharmacol511, 73-74, (2005).
Cendan, C.M.,Pujalte, J.M.,Portillo-Salido, E.,Montoliu, L.,&Baeyens, J.M.
View abstract in PubMed

“Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma-1 receptor: Optical imaging study in rat hippocampal slices. ” Neuropharmacology 50, 380-392, (2006).
Chen, L., Dai, X. N., & Sokabe, M.
View abstract in PubMed

“Neurosteroid dehydroepiandrosterone sulfate inhibits persistent sodium current in rat medial prefrontal cortex via activation of sigma-1 receptors. ” Exp Neurol 210, 128-136, (2008).
Cheng, Z. X., Lan, D. M., Wu, P. Y., Zhu, Y. H., Dong, Y., Ma, L., et al.
View abstract in PubMed

“Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. ” Brain Res 821, 516-519, (1999).
Chou, Y. C., Liao, J. F., Chang,W. Y., Lin, M. F., & Chen, C. F.
View abstract in PubMed

“Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell line. ” Cancer Res 62, 313-322, (2002).
Crawford, K. W., & Bowen, W. D.
View abstract in PubMed

“Sigma-2 receptors regulate changes in sphingolipid levels in breast tumor cells. ” Eur J Pharmacol 443, 207-209, (2002).
Crawford, K.W., Coop, A., & Bowen,W. D.
View abstract in PubMed

“Possible involvement of sigma-1 receptors in the antiimmobility action of buproprion, a dopamine reuptake inhibitor. ” Fundam Clin Pharmacol 22, 387-394, (2008).
Dhir, A., & Kulkarni, S. K.
View abstract in PubMed

“Prevention of excitotoxicity in primary retinal ganglion cells by (+)pentazocine, a sigma-1 receptor specific ligand. ” Invest Ophthalmol Vis Sci 48, 4785-4794, (2007).
Dun, Y., Thangaraju, M., Prasad, P., Ganapathy, V., & Smith, S. B.
View abstract in PubMed

“Evidence for an anti-amnesic effect of JO 1784 in the rat: A potent and selective ligand for the sigma receptor. ” Brain Res 546, 282-286, (1991).
Earley, B., Burke, M., Leonard, B. E., Gouret, C. J., & Junien, J. L.
View abstract in PubMed

“Involvement of the sigma-1 receptor in the anti-amnesic, but not antidepressant-like, effects of the aminotetrahydrofuran derivative ANAVEX-41. ” Br J Pharmacol 152, 267-279, (2007).
Espallergues, J., Lapalud, P., Christopoulos, A., Avlani, V. A., Sexton, P. M., Vamvakides, A., et al.
View abstract in PubMed

“The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. ” Science 323, 934-937, (2009).
Fontanilla, D., Johannessen, M., Hajipour, A. R., Cozzi, N. V., Jacjson, M. B., & Ruoho, A. E.
View abstract in PubMed

“Cocaine modulates cytokine and enhances tumor growth through sigma receptors. ” J Neuroimmunol 147, 95-98, (2004).
Gardner, B., Zhu, L. X., Roth, M. D., Tashkin, D. P., Dubinett, S. M., & Sharma, S.
View abstract in PubMed

“Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1. ” Int Immunopharmacol 6, 1029-1033, (2006).
Gekker, G., Hu, S., Sheng, W. S., Rock, R. B., Lokensgard, J. R., & Peterson, P. K.
View abstract in PubMed

“Potent sigma-1 receptor ligand 4-phenyl-1-(4-phenylbutyl)piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats. ” Anesth Analg 96, 532-538, (2003).
Goyagi, T., Bhardwaj, A., Koehler, R. C., Traystman, R. J., Hurn, P. D., & Kirsch, J. R.
View abstract in PubMed

“Neuroprotective effect of sigma-1 receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production. ” Stroke 32, 1613-1620, (2001).
Goyagi, T., Goto, S., Bhardwaj, A., Dawson, V. L., Hurn, P. D., & Kirsch, J. R.
View abstract in PubMed

“Sigma receptors: Biology and therapeutic potential. ” Psychopharmacology (Berl) 174, 301-319, (2004).
Guitart, X., Codony, X., & Monroy, X.
View abstract in PubMed

“Sigma-1 receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion. ” Stroke 31, 976-982, (2000).
Harukuni, I., Bhardwaj, A., Shaivitz, A. B., DeVries, A. C., London, E. D., Hurn, P. D., et al.
View abstract in PubMed

“Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: Role of sigma-1 receptors. ” Neuropsychopharmacology 32, 514-521, (2007).
Hashimoto, K., Fujita, Y., & Iyo, M.
View abstract in PubMed

“Regulating ankyrin dynamics: Roles of sigma-1 receptors. ” Proc Natl Acad Sci USA 98, 491-496, (2001).
Hayashi, T., & Su, T. P.
View abstract in PubMed

“Intracellular dynamics of sigma-1 receptors in NG-108- 15 cells. ” J Pharmacol Exp Ther 306, 726-733, (2003a).
Hayashi, T., & Su, T. P.
View abstract in PubMed

“Sigma-1 receptor (s1 binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: Roles in endoplasmic reticulum lipid compartmentalization and export. ” J Pharmacol Exp Ther 306, 718-725, (2003b).
Hayashi, T., & Su, T. P.
View abstract in PubMed

“Sigma-1 receptor chaperones at the ER mitochondrion interface regulate Ca2+ signaling and cell survival. ” Cell 131, 596-610, (2007).
Hayashi, T., & Su, T. P.
View abstract in PubMed

“Rat liver and kidney contain high densities of sigma-1 and sigma-2 receptors: Characterization by ligand binding and photoaffinity labeling. ” Eur J Pharmacol 268, 9-18, (1994).
Hellewell, S. B., Bruce, A., Feinstein, G., Orringer, J.,Williams,W., & Bowen,W. D.
View abstract in PubMed

“Sigma-1 receptor modulation of acid-sensing ion channel 1a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons. ” J Pharmacol Exp Ther 327, 491-502, (2008).
Herrera, Y., Katnik, C., Rodriguez, J. D., Hall, A. A., Willing, A., Pennypacker, K. R., et al.
View abstract in PubMed

“Olfactory bulbectomy increases prepro-enkephalin mRNA levels in the ventral striatum in rats. ” Neuropeptides 33, 206-211, (1999).
Holmes, P. V.
View abstract in PubMed

“No association found between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population: A collaborative study by the Japanese Genetics Initiative for Drug Abuse. ” Ann NY Acad Sci 1025, 27-33, (2004).
Inada, T., Iijima, Y., Uchida, N., Maeda, T., Iwashita, S., Ozaki, N., et al.
View abstract in PubMed

“Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia. ” Neurosci Lett 257, 45-48, (1998).
Ishiguro, H., Ohtsuki, T., Toru, M., Itokawa, M., Aoki, J., Shibuya, H., et al.
View abstract in PubMed

“Fluovoxamine as a sigma-1 receptor agonist improved cognitive impairments in a patientwith schizophrenia. ” ProgNeuropsychopharmacol Biol Psychiatry 32,1072-1703, (2008).
Iyo, M., Shirayama, Y., Watanabe, H., Fujisaki, M., Miyatake, R., Fukami, G., et al.
View abstract in PubMed

“Loss of sigma binding sites in the CA1 area of the anterior hippocampus in Alzheimer's disease correlates with CA1 pyramidal cell loss. ” Brain Res 623, 299-302, (1993).
Jansen, K. L., Faull, R. L., Storey, P., & Leslie, R. A.
View abstract in PubMed

“Brain circuitry and the reinstatement of cocaineseeking behavior. ” Psychopharmacology (Berl) 168, 44-56, (2003).
Kalivas, P.W., & McFarland, K.
View abstract in PubMed

“Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. ” J Pharmacol Exp Ther 319, 1355-1365, (2006).
Katnik, C., Guerrero, W. R., Pennypacker, K. R., Herrera, Y., & Cuevas, J.
View abstract in PubMed

“TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. ” Neurosci Lett 260, 5-8, (1999).
Kato, K., Hayako, H., Ishihara, Y., Marui, S., Iwane, M., & Miyamoto, M.
View abstract in PubMed

“Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. ” FASEB J 22, 93-104, (2008).
Kibaly, C., Meyer, L., Patte-Mensah, C., & Mensah-Nyagan, A. G.
View abstract in PubMed

“Intrathecal treatment with sigma-1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice. ” Br J Pharmacol 148, 490-498, (2006).
Kim, H. W., Kwon, Y. B., Roh, D. H., Yoon, S. Y., Han, H. J., Beitz, A. J., et al.
View abstract in PubMed

“Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKAdependent phosphorylation of theNR1 subunit inmice. ” Br J Pharmacol 154,1125-1134, (2008).
Kim, H.W., Roh, D. H., Yoon, S. Y., Seo, H. s., Kwon, Y. B., Han, H. J., et al.
View abstract in PubMed

“Enhanced kappaopioid receptor-mediated analgesia by antisense targeting the sigma-1 receptor. ” Eur J Pharmacol 331, R5-6, (1997).
King, M., Pan, Y. X., Mei, J., Chang, A., Xu, J., & Pasternak, G.W.
View abstract in PubMed

“Sigma- 1 receptor antagonists determine the behavioral pattern of the methamphetamineinduced sterotypy in mice. ” Psychopharmacology (Berl) 203, 781-792, (2008).
Kitanaka, J., Kitanaka, N., Tatsuta, T., Hall, F. S., Uhl, G. R., Tanaka, K., et al.
View abstract in PubMed

“Alterations in fos-related antigen 2 and sigma-1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: Time course and regional distribution studies. ” J Pharmacol Exp Ther 327, 187-195, (2008).
Liu, Y., & Matsumoto, R. R.
View abstract in PubMed

“Further evidence for an antidepressant potential of the selective sigma-1 agonist SA4503: Electrophysiological, morphological and behavioral studies. ” Int J Neuropsychopharmacol 11, 485-495, (2008).
Lucas, G., Rymar, V. V., Sadikot, A. F., & Debonnel, G.
View abstract in PubMed

“Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP. ” J Physiol 526, 527-539, (2000).
Lupardus, P. J., Wilke, R. A., Aydar, E., Palmer, C. P., Chen, Y., Ruoho, A. E., et al.
View abstract in PubMed

“Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice. ” Neuropharmacology 39, 2391-2398, (2000).
Mamiya, T., Noda, Y., Noda, A., Hiramatsu, M., Karasawa, K., Kameyama, T., et al.
View abstract in PubMed

“Neuroprotective effects of sigma-1 receptor agonists against β-amyloid-induced toxicity. ” Neuroreport 16, 1223-1226, (2005).
Marrazzo, A., Caraci, F., Salinaro, E. T., Su, T. P., Copani, A., & Ronsisvalle, G.
View abstract in PubMed

“The sigma receptor ligand (+)pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. ” Brain Res Mol Brain Res 123, 66-75, (2004)
Martin, P.M., Ola, M. S., Agarwal, N., Ganapathy, V.,&Smith, S. B.
View abstract in PubMed

“The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. ” J Pharmacol Exp Ther 197, 517-532, (1976)
Martin, W. R., Eades, C. G., Thompson, J. A., Huppler, R. E., & Gilbert, P. E.
View abstract in PubMed

“The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus. ” J Physiol 578, 143-157, (2007)
Martina, M., Turcotte, M. E., Halman, S., & Begeron, R.
View abstract in PubMed

“Blockade of σ1 receptors attenuates conditioned reinstatement but not self-administration maintained by cocaine or a potent conventional reinforcer. ” Neuropsychopharmacology 32, 1967-1973, (2007)
Martin-Fardon, R., Maurice, T., Aujla, H., Bowen,W. D., &Weiss, F.
View abstract in PubMed

“Sigma receptor type 1 gene expression variation in a group of Polish patients with Alzheimer's disease and mild cognitive impairment. ” Demen Geriatr Cogn Disord 23, 432-438, (2007)
Maruszak, A., Safranow, K., Gacia, M., Gabryelewicz, T., Slowik, A., Styczynska, M., et al.
View abstract in PubMed

“Sigma receptors: Potential medications development target for anti-cocaine agents. ” Eur J Pharmacol 469, 1-12 ,(2003).
Matsumoto, R. R., Liu, Y., Lerner, M., Howard, E. W., & Brackett, D. J.
View abstract in PubMed

“Involvement of sigma receptors in the behavioral effects of cocaine: Evidence from novel ligands and antisense oligodeoxynucleotides. ” Neuropharmacology 42, 1043-1055, (2002)
Matsumoto, R. R.,McCracken, K. A., Pouw, B., Zhang, Y.,&Bowen,W. D.
View abstract in PubMed

“Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex. ” J Pharmacol Exp Ther 265,851-859, (1993)
Matsuno, K., Matsunaga, K., Senda, T., & Mita, S.
View abstract in PubMed

“Beneficial effect of the sigma-1 receptor agonist PRE-084 against the spatial learning deficits in aged rats. ” Eur J Pharmacol 431, 223-227, (2001)
Maurice, T.
View abstract in PubMed

“Neurosteroids and sigma1 receptors, biochemical and behavioral relevance. ” Pharmacopsychiatry 37, S171-S182, (2004)
Maurice, T.
View abstract in PubMed

“Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands. ” Prog Neuropsychopharmacol Biol Psychiatry 21, 69-102, (1997)
Maurice, T., & Lockhart, B. P.
View abstract in PubMed

“SA4503, a novel cognitive enhancer with sigma1receptor agonist properties, facilitates NMDA receptor-dependent learning in mice. ” Eur J Pharmacol 328, 9-18, (1997).
Maurice, T., & Privat, A.
View abstract in PubMed

“Involvement of the sigma1 receptor in the appetitive effects of cocaine. ” Pharmacopsychiatry 37, S198-207, (2004)
Maurice, T., & Romieu, P.
View abstract in PubMed

“Involvement of the sigma-1 receptor in the motivational effects of ethanol in mice. ” Pharmacol Biochem Behav 74, 869-876, (2003).
Maurice, T., Casalino, M., Lacroix, M., & Romieu, P.
View abstract in PubMed

“Differential involvement of the sigma-1 receptor in the anti-amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse. ” Br J Pharmacol 134, 1731-1741, (2001).
Maurice, T., Phan, V., Urani, A., & Guillemain, I.
View abstract in PubMed

“Neuroactive neurosteroids as endogenous effectors for the sigma1 (σ1) receptor: Pharmacological evidence and therapeutic opportunities. ” Jpn J Pharmacol 81, 125-155, (1999).
Maurice, T., Phan, V. L., Urani, A., Kamei, H., Noda, Y., & Nabeshima, T.
View abstract in PubMed

“PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice. ” Pharmacol Biochem Behav 49, 859-869, (1994).
Maurice, T., Su, T. P., Parish, D. W., Nabeshima, T., & Privat, A.
View abstract in PubMed

“Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25-35-amyloid peptide-induced amnesia in mice through a common mechanism. ” Neuroscience 83, 413-428, (1998).
Maurice, T., Su, T. P., & Privat, A.
View abstract in PubMed

“The interaction between neuroactive steroids and the sigma1 receptor function: Behavioral consequences and therapeutic opportunities. ” Brain Res Brain Res Rev 37, 116-132, (2001).
Maurice, T., Urani, A., Phan, V. L., & Romieu, P.
View abstract in PubMed

“Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells. ” J Mol Signal 2, 8, (2007).
Mavlyutov, T. A., & Ruoho, A.
View abstract in PubMed

“4-IBP, a sigma-1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vivo and sensitizes them in vitro to cytotoxic insults of proapoptotic and proautophagic drugs. ” Neoplasia 9, 358-369, (2007).
Megalizzi, V., Mathieu, V., Mijatovic, T., Gailly, P., Debeir, O., De Neve, N., et al.
View abstract in PubMed

“Molecular cloning and pharmacological characterization of the rat σ1 receptor. ” Biochem Pharmacol 62, 349-355, (2001).
Mei, J., & Pasternak, G. W.
View abstract in PubMed

“σ1 Receptor modulation of opioid analgesia in the mouse. ” J Pharmacol Exp Ther 300, 1070-1074, (2002).
Mei, J., & Pasternak, G. W.
View abstract in PubMed

“Modulation of brainstem opiate analgesia in the rat by σ1 receptor: A microinjection study. ” J Pharmacol Exp Ther 322, 1278-1285, (2007).
Mei, J., & Pasternak, G.W.
View abstract in PubMed

“Beneficial effects of the σ1 receptor agonists igmesine and dehydroepiandrosterone against learning impairments in rats prenatally exposed to cocaine. ” Neurotoxicol Teratol 26, 783-797, (2004).
Meunier, J., & Maurice, T.
View abstract in PubMed

“Antiamnesic and neuroprotective effects of donepezil against learning impairment induced in mice by exposure to carbon monoxide gas. ” J Pharmacol Exp Ther 317, 1307-1319, (2006a).
Meunier, J., Ieni, J., & Maurice, T.
View abstract in PubMed

“The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor. ” Br J Pharmacol 149, 998-1012, (2006b).
Meunier, J., Ieni, J., & Maurice, T.
View abstract in PubMed

“Lowdensity of sigma-1 receptors in early Alzheimer's disease. ” Ann Nucl Med 22, 151-156, (2008).
Mishina, M.,Ohyama,M., Ishii, K., Kitamura, S., Kimura,Y.,Oda, K., et al.
View abstract in PubMed

“Functional polymorphisms in the σ1 receptor gene associated with alcoholism. ” Biol Psychiatry 55, 85-90, (2004).
Miyatake, R., Furukawa, A., Matsushita, S., Higuchi, S., & Suwaki, H.
View abstract in PubMed

“The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: Molecular, physiological, and behavioral aspects. ” J Pharmacol Sci 100, 93-118, (2006).
Monnet, F. P., & Maurice, T.
View abstract in PubMed

“N-methyl-Daspartate- induced neuronal activation is selectively modulated by sigma receptors. ” Eur J Pharmacol 179, 441-445, (1990).
Monnet, F. P., Debonnel, G., Junien, J. L., & De Montigny, C.
View abstract in PubMed

“Protein kinase Cdependent potentiation of intracellular calcium influx by σ1 receptor agonists in rat hippocampal neurons. ” J Pharmacol Exp Ther 307, 705-712, (2003).
Monnet, F. P., Morin-Surun, M. P., Leger, J., & Combettes, L.
View abstract in PubMed

“Intracellular σ1 receptor modulates phospholipase C and protein kinase C activities in the brainstem. ” Proc Natl Acad Sci USA 96, 8196-8199, (1999).
Morin-Surun, M. P., Collin, T., Denavit-Saubie, M., Baulieu, E. E., & Monnet, F. P.
View abstract in PubMed

“Haloperidol-associated stealth liposomes: A potent carrier for delivering genes to human cancer cells. ” J Biol Chem 280, 15619-15627, (2005).
Mukherjee, A., Prasad, T. K., Rao, N. M., & Banerjee, R.
View abstract in PubMed

“Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain. ” Eur J Pharmacol 307, 117-119, (1996).
Narita, N., Hashimoto, K., Tomitaka, S., & Minabe, Y.
View abstract in PubMed

“Involvement of sigma receptors in the acute actions of methamphetamine: Receptor binding and behavioral studies. ” Neuropharmacology 49, 638-645, (2005).
Nguyen, E. C., McCracken, K. A., Liu, Y., Pouw, B., & Matsumoto, R. R.
View abstract in PubMed

“Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina. ” Brain Res Mol Brain Res 95, 86-95, (2001).
Ola, M. S., Moore, P., El-Sherbeny, A., Roon, P., Agarwal, N., Sarthy, V. P., Casellas, P., et al.
View abstract in PubMed

“Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysomal leakage and oxidative stress. ” Cancer Res 65, 8975-8983, (2005).
Ostenfeld, M. S., Fehrenbacher, N., Hoyer-Hansen, M., Thomsen, C., Farkas, T., & Jaattela, M.
View abstract in PubMed

“Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines. ” Cancer Res 67, 11166-11175, (2007).
Palmer, C. P., Mahen, R., Schnell, E., Djamgoz, M. B., & Aydar, E.
View abstract in PubMed

“A new sigma ligand, (+/-)PPCC, antagonizes kappa opioid receptormediated antinociceptive effect. ” Life Sci 82, 549-553, (2008).
Prezzavento, O., Parenti, C., Marrazzo, A., Ronsisvalle, S., Vittorio, F., Arico, G., et al.
View abstract in PubMed

“Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl-channels. ” J Biol Chem 282, 2259-2267, (2007).
Renaudo, A., L'Hoste, S., Guizouarn, H., Borgese, F., & Soriani, O.
View abstract in PubMed

“Inhibition of tumor cell proliferation by sigma ligands is associated with K+channel inhibition and p27kip accumulation. ” J Pharmacol Exp Ther 311, 1105-1114, (2004).
Renaudo, A., Watry, V., Chassot, A. A., Ponzio, G., Ehrenfeld, J., & Soriani, O.
View abstract in PubMed

“Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids. ” J Endocrinol 182, 11-21, (2004).
Robichaud, M., & Debonnel, G.
View abstract in PubMed

“Intrathecal administration of sigma-1 receptor agonists facilitates nociception: Involvement of protein kinase C-dependent pathway. ” J Neurosci Res 86, 3644-3654, (2008a).
Roh, D. H., Kim, H.W., Yoon, S. Y., Seo, H. S., Kwon, Y. B., & Kim, K.W.
View abstract in PubMed

“Intrathecal injection of sigma-1 receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain. ” Anesthesiology 109, 879-889, (2008b).
Roh, D. H., Kim, H. W., Yoon, S. Y., Seo, H. S., Kwon, Y. B., Kim, K. W., et al.
View abstract in PubMed

“Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference. ” Neuroreport 11, 2885-2888, (2000).
Romieu, P., Martin-Fardon, R., & Maurice, T.
View abstract in PubMed

“Involvement of the sigma1 receptor in cocaine-induced conditioned place preference: Possible dependence on dopamine uptake blockade. ” Neuropsychopharmacology 26, 444-455, (2002).
Romieu, P., Phan, V. L.,Martin-Fardon, R., & Maurice, T.
View abstract in PubMed

“Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model. ” J Leukoc Biol 78, 1198-1203, (2005).
Roth, M. D., Whittaker, K. M., Choi, R., Tashkin, D. P., & Baldwin, G. C.
View abstract in PubMed

“Emergence ofNMDAR-independent long-termpotentiation at hippocampal CA1 synapses following early adolescent exposure to chronic intermittent ethanol: Role for sigma-receptors. ” Hippocampus 18, 148-168, (2008).
Sabeti, J., & Gruol, D. L.
View abstract in PubMed

“Steroid pregnenolone sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses: Role for L-type calcium channels and sigma receptors. ” Hippocampus 17, 349-369, (2007).
Sabeti, J., Nelson, T. E., Purdy, R. H., & Groul, D. L.
View abstract in PubMed

“Sigma-1 receptor knockout mice display a depressive-like phenotype. ” Behav Brain Res 198, 472-476, (2009).
Sabino, V., Cottone, P., Parylak, S. L., Steardo, L., & Zorrilla, E. P.
View abstract in PubMed

“Lack of association between sigma receptor gene variants and schizophrenia. ” Psychiatyr Clin Neurosci 58, 359-363, (2004).
Satoh, F., Miyatake, R., Furukawa, A., & Suwaki, H.
View abstract in PubMed

“Cloning and functional characterization of a sigma receptor from rat brain. ” J Neurochem 70, 922-931, (1998).
Seth, P., Fei, Y. J., Li, H.W., Huang,W., Leibach, F. H., & Ganapathy, V.
View abstract in PubMed

“Cocaine binding at sigma receptors. ” Eur J Pharmacol 149, 171-174, (1988).
Sharkey, J., Glen, K. A., Wolfe, S., & Kuhar, M. J.
View abstract in PubMed

“Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation. ” J Neurochem 104, 558-572, (2008).
Shen, Y. C., Wang, Y. H., Chou, Y. C., Liou, K. T., Yen, J. C., Wang, W. Y., et al.
View abstract in PubMed

“How cells handle cholesterol. ” Science 290, 1721-1726, (2000).
Simons, K., & Ikonen, E.
View abstract in PubMed

“A npotential antidepressant activity of SA4503, a selective sigma-1 receptor agonist. ” Behav Pharmacol 13, 537-543, (2002).
Skuza, G., & Rogoz, Z.
View abstract in PubMed

“Sigma-1 receptor antagonists attenuate antidepressantlike effect induced by co-administration of 1,3di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats. ” Pol J Pharmacol 55, 1149-1152, (2003).
Skuza, G., & Rogoz, Z.
View abstract in PubMed

“In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+) pentazocine. ” Invest Ophthamol Vis Sci 49, 4154-4161, (2008).
Smith, S. B., Duplantier, J., Dun, Y., Mysona, B., Roon, P., Martin, P. M., et al.
View abstract in PubMed

“A-current down-modulated by sigma receptor in frog pituitary melanotrope cells through a G-protein-dependent pathway. ” J Pharmacol Exp Ther 289, 321-328, (1999a).
Soriani, O., Foll, F. L., Roman, F., Monnet, F. P., Vaudry, H., & Cazin, L.
View abstract in PubMed

“Small molecule antagonists of the sigma-1 receptor cause selective release of the death programin tumorand self-reliant cells and inhibit tumor growth in vitro and in vivo. ” Cancer Res 64, 4875-4886, (2004).
Spruce, B. A., Campbell, L. A.,McTavish, N., Cooper, M. A., Appleyard, M. V., O'Neill,M., et al.
View abstract in PubMed

“Sigma-1 receptor upregulation after chronic methamphetamine self-administration in rats: A study with yoked controls. ” Psychopharmacology 175, 68-75, (2004).
Stefanski, R., Justinova, Z., Hayashi, T., Takebayashi, M., Goldberg, S. R., & Su, T. P.
View abstract in PubMed

“When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor. ” Science-Signaling 2(61) pe12, (2009, March 10).
Su, T. P., Hayashi, T., & Vaupel, D. B.
View abstract in PubMed

“Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems. ” Science 240, 219-221, (1988).
Su, T. P., London, E. D., & Jaffe, J. H.
View abstract in PubMed

“Involvement of sigma-1 receptors in methamphetamine-induced behavioral sensitization in rats. ” Neurosci Lett 289, 21-24, (2000).
Takahashi, S., Miwa, T., & Horikomi, K.
View abstract in PubMed

“Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis: Potential relation to lipid raft reconstitution. ” Synapse 53, 90-103, (2004).
Takebayashi, M., Hayashi, T., & Su, T. P.
View abstract in PubMed

“Sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation. ” Invest Ophthalmol Vis Sci 49, 2577-2588, (2008).
Tchedre, K. T., & Yorio, T.
View abstract in PubMed

“No association between the sigma receptor type 1 gene and schizophrenia: Results of analysis and meta-analysis of case-control studies. ” BMC Psychiatry 3, 13, (2003).
Uchida, N., Ujike, H., Nakata, K., Takaki, M., Nomura, A., Katsu, T., et al.
View abstract in PubMed

“A variant of the sigma receptor type 1 gene is a protective factor for Alzheimer's disease. ” Am J Geriatr Psychiatry 13, 1062-1066, (2005).
Uchida, N., Ujike, H., Tanaka, Y., Sakai, A., Yamamoto, M., Fujisawa, Y., et al.
View abstract in PubMed

“Beneficial effects of acute and repeated administrations of sigma receptor agonists on behavioural despair in mice exposed to tail suspension. ” Pharmacol Biochem Behav 61, 247-252, (1998).
Ukai, M., Maeda, H., Nanya, Y., Kameyama, T., & Matsuno, K.
View abstract in PubMed

“The antidepressant-like effect induced by sigma-1 receptor agonists and neuroactive steroids in mice submitted to the forced swimming test. ” J Pharmacol Exp Ther 298, 1269-1279, (2001).
Urani, A., Roman, F. J., Phan, V., Su, T. P., & Maurice, T.
View abstract in PubMed

“Enhanced antidepressant effect of sigma-1 receptor agonists in β25-35-amyloid peptide-treated mice. ” Behav Brain Res 134, 239-247, (2002).
Urani, A., Romieu, P., Roman, F. J., & Maurice, T.
View abstract in PubMed

“Sigma-1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase. ” Anesth Analg 103, 430-434, (2006).
Vagnerova, K., Hurn, P. D., Bhardwaj, A., & Kirsch, J. R.
View abstract in PubMed

“Antiamnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid beta(25-35)- induced toxicity in ice. ” Neuropsychopharmacology 34, 1552-1566, (2009).
Villard, V., Espallergues, J., Keller, E., Alkam, T., Nitta, A., Yamada, K., Nabeshima, T., Vamvakides, A., & Maurice, T.
View abstract in PubMed

“Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. ” Cancer Res 55, 408-413, (1995).
Vilner, B. J., John, C. S., & Bowen, W. D.
View abstract in PubMed

“Clinical trials with sigma ligands. ” Pharmacopsychiatry 37, S214-S220, (2004).
Volz, H. P., & Stoll, K. D.
View abstract in PubMed

“Silencing of sigma-1 receptor induces cell death in human lens cells. ” Exp Cell Res 312, 1439-1446, (2006).
Wang, L., & Duncan, G.
View abstract in PubMed

“Expression of sigma-1 receptor in human breast cancer. ” Breast Cancer Res Treat 87, 205-214, (2004).
Wang, B., Rouzier, R., Albarracin, C. T., Sahin, A., Wagner, P., Yang, Y., et al.
View abstract in PubMed

“Anti-amnesic effect of dimemorfan in mice. ” Br J Pharmacol 138, 941-949, (2003).
Wang, H. H., Chien, J.W., Chou, Y. C., Liao, J. F., & Chen, C. F.
View abstract in PubMed

“Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation. ” Invest Ophthalmol Vis Sci 46, 1403-1408, (2005).
Wang, L., Prescott, A. R., Spruce, B. A., Sanderson, J., & Duncan, G.
View abstract in PubMed

“Haloperidol induces apoptosis via the sigma-2 receptor system and BCl-XS. ” Pharmacogenomics 6, 279-288, (2006).
Wei, Z., Mousseau, D. D., Dai, Y., Cao, X., & Li, X. M.
View abstract in PubMed

“Sigma receptor photolabeling and sigma receptor-mediated modulation of potassium channels in tumor cells. ” J Biol Chem 274, 1837-18392, (1999).
Wilke, R. A., Mehta, R. P., Lupardus, P. J., Chen, Y., Ruoho, A. E., & Jackson, M. B.
View abstract in PubMed

“Overexpression of sigma receptors in nonneural human tumors. ” Cancer Research 51, 6558-6562, (1991).
Wojciech, T. B., Thomas, G. E., Mamone, J. Y., Homan, S. M., Levy, B. K., Johnson, F. R. E., et al.
View abstract in PubMed

“Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: Constitutive enhancement of calcium signaling in MCF-7 tumor cells. ” J Biol Chem 283, 28198-28215, (2008).
Wu, Z., & Bowen,W. D.
View abstract in PubMed

“Animal models of Alzheimer's disease and evaluation of anti-dementia drugs. ” Pharmacol Ther 88, 93-113, (2000).
Yamada, K., & Nabeshima, T.
View abstract in PubMed

“Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2. ” Anesth Analg 104, 1179-1184, (2007).
Yang, S., Bhardwaj, A., Cheng, J., Alkayed, N. J., Hurn, P. D., & Kirsch, J. R.
View abstract in PubMed

“Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. ” J Neurophysiol 87, 2867-2879, (2002).
Zhang, H., & Cuevas, J.
View abstract in PubMed

“Sigma receptor activation blocks potassium channels and depresses neuroexcitaibility in rat intracardiac neurons. ” J Pharmacol Exp Ther 313, 1387-1396, (2005).
Zhang, H., & Cuevas, J.
View abstract in PubMed

“IL-10 mediates sigma-1 receptor-dependent suppression of antitumor immunity. ” J Immunol 170, 3585-3591, (2003).
Zhu, L. X., Sharma, S., Gardner, B., Escuadro, B., Atianzar, K., Tashkin, D. P., et al.
View abstract in PubMed

“Effects of sigma-1 receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in mice. ” Neuropharmacology 39, 1617-1627, (2000).
Zou, L. B., Yamada, K., Sasa, M., Nakata, Y., & Nabeshima, T.
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